diff --git a/easybuild/easyconfigs/c/CastXML/CastXML-0.6.13-GCCcore-14.2.0.eb b/easybuild/easyconfigs/c/CastXML/CastXML-0.6.13-GCCcore-14.2.0.eb
new file mode 100644
index 000000000000..0fa7339aaec2
--- /dev/null
+++ b/easybuild/easyconfigs/c/CastXML/CastXML-0.6.13-GCCcore-14.2.0.eb
@@ -0,0 +1,32 @@
+easyblock = 'CMakeMake'
+
+name = 'CastXML'
+version = '0.6.13'
+
+homepage = 'https://github.com/CastXML/CastXML'
+description = """CastXML is a C-family abstract syntax tree XML output tool."""
+
+toolchain = {'name': 'GCCcore', 'version': '14.2.0'}
+
+github_account = 'CastXML'
+source_urls = [GITHUB_SOURCE]
+sources = ['v%(version)s.tar.gz']
+checksums = ['df954886464fe624887411e5f4e2a7db00da3d64a48f142d3aff973e2097e2d6']
+
+builddependencies = [
+    ('binutils', '2.42'),
+    ('CMake', '3.31.3'),
+]
+
+dependencies = [
+    ('LLVM', '20.1.7'),
+    ('ncurses', '6.5'),
+    ('zlib', '1.3.1'),
+]
+
+sanity_check_paths = {
+    'files': ['bin/castxml'],
+    'dirs': ['share/castxml'],
+}
+
+moduleclass = 'tools'
diff --git a/easybuild/easyconfigs/i/ITK/ITK-5.4.5-foss-2025a.eb b/easybuild/easyconfigs/i/ITK/ITK-5.4.5-foss-2025a.eb
new file mode 100644
index 000000000000..70f5a05d317d
--- /dev/null
+++ b/easybuild/easyconfigs/i/ITK/ITK-5.4.5-foss-2025a.eb
@@ -0,0 +1,89 @@
+# Contributors:
+# Fenglai Liu (fenglai@accre.vanderbilt.edu) - Vanderbilt University
+# Alex Domingo (alex.domingo.toro@vub.be) - Vrije Universiteit Brussel (VUB)
+# Denis Kristak (INUITS), Pavel Tománek (INUITS)
+# Update: Petr Král (INUITS)
+
+easyblock = 'CMakeMake'
+
+name = 'ITK'
+version = '5.4.5'
+
+homepage = 'https://itk.org'
+description = """Insight Segmentation and Registration Toolkit (ITK) provides
+ an extensive suite of software tools for registering and segmenting
+ multidimensional imaging data."""
+
+toolchain = {'name': 'foss', 'version': '2025a'}
+
+github_account = 'InsightSoftwareConsortium'
+source_urls = [GITHUB_SOURCE]
+sources = ['v%(version)s.tar.gz']
+patches = [
+    'ITK-5.3.0_add-vtk-include-dir.patch',
+]
+checksums = [
+    {'v5.4.5.tar.gz': 'bb53785b9803ed2dc4fd6b395f6fe089fcdbdfdeb9242549257b9adcefc9f73e'},
+    {'ITK-5.3.0_add-vtk-include-dir.patch': 'df7e834a024db5d1a1459d898bd43a044351e29759ab0bf69ce03d64da95b3f7'},
+]
+
+builddependencies = [
+    ('CMake', '3.31.3'),
+    ('Bison', '3.8.2'),
+    ('Eigen', '3.4.0'),
+    ('SWIG', '4.3.1'),
+    ('Perl', '5.40.0'),
+    ('git', '2.49.0'),
+]
+dependencies = [
+    ('Python', '3.13.1'),
+    ('SciPy-bundle', '2025.06'),
+    ('double-conversion', '3.3.1'),
+    ('expat', '2.6.4'),
+    ('HDF5', '1.14.6'),
+    ('libjpeg-turbo', '3.1.0'),
+    ('libpng', '1.6.48'),
+    ('LibTIFF', '4.7.0'),
+    ('VTK', '9.5.0'),
+    ('zlib', '1.3.1'),
+    ('CastXML', '0.6.13'),
+]
+
+# Features
+configopts = '-DBUILD_SHARED_LIBS=ON -DBUILD_TESTING=OFF '
+configopts += '-DModule_ITKReview=ON -DModule_ITKVtkGlue=ON -DModule_SimpleITKFilters=ON '
+# Enable Python bindings
+configopts += '-DITK_WRAP_PYTHON:BOOL=ON -DPython3_EXECUTABLE=$EBROOTPYTHON/bin/python '
+configopts += '-DSWIG_EXECUTABLE=$EBROOTSWIG/bin/swig -DSWIG_DIR=$EBROOTSWIG '
+configopts += '-DPY_SITE_PACKAGES_PATH=%(installdir)s/lib/python%(pyshortver)s/site-packages '
+# Dependencies from EB
+local_sys_deps = [
+    'CASTXML',
+    'DOUBLECONVERSION',
+    'EIGEN',
+    'EXPAT',
+    'FFTW',
+    'HDF5',
+    'JPEG',
+    'PNG',
+    'SWIG',
+    'TIFF',
+    'ZLIB'
+]
+local_sys_cmake = ['-DITK_USE_SYSTEM_%s=ON' % d for d in local_sys_deps]
+configopts += ' '.join(local_sys_cmake)
+
+prebuildopts = 'LC_ALL=C '
+
+local_lib_names = ['ITKCommon', 'ITKIOHDF5', 'ITKIOJPEG', 'ITKIOPNG', 'ITKIOTIFF',
+                   'ITKReview', 'ITKVTK', 'ITKVtkGlue', 'itkSimpleITKFilters']
+
+sanity_check_paths = {
+    'files': ['bin/itkTestDriver'] +
+             ['lib/lib%s-%%(version_major)s.%%(version_minor)s.%s' % (lname, SHLIB_EXT) for lname in local_lib_names],
+    'dirs': ['include/ITK-%(version_major)s.%(version_minor)s', 'lib/python%(pyshortver)s/site-packages', 'share'],
+}
+
+sanity_check_commands = ["python -s -c 'import itk'"]
+
+moduleclass = 'data'
diff --git a/easybuild/easyconfigs/s/SimpleITK/SimpleITK-2.5.3-foss-2025a.eb b/easybuild/easyconfigs/s/SimpleITK/SimpleITK-2.5.3-foss-2025a.eb
new file mode 100644
index 000000000000..1551b29bcb1d
--- /dev/null
+++ b/easybuild/easyconfigs/s/SimpleITK/SimpleITK-2.5.3-foss-2025a.eb
@@ -0,0 +1,48 @@
+easyblock = 'CMakeMake'
+
+name = 'SimpleITK'
+version = '2.5.3'
+
+homepage = 'https://www.simpleitk.org'
+description = """SimpleITK is a simplified programming interface to the algorithms and data structures of
+ the Insight Toolkit (ITK)."""
+
+toolchain = {'name': 'foss', 'version': '2025a'}
+
+source_urls = ['https://github.com/%(name)s/%(name)s/releases/download/v%(version)s']
+sources = [SOURCE_TAR_GZ]
+checksums = ['1ef3642b0695c8eb0a0193fefe7677c57bce94a86d6b01f48f58b2291b4ca935']
+
+builddependencies = [
+    ('CMake', '3.31.3'),
+    ('SWIG', '4.3.1'),
+    ('Lua', '5.4.8'),
+]
+
+dependencies = [
+    ('Python', '3.13.1'),
+    ('ITK', '5.4.5'),
+    ('scikit-build', '0.18.1'),
+]
+
+# Enable Python bindings
+configopts = "-DWRAP_DEFAULT:BOOL=OFF -DWRAP_PYTHON=BOOL:ON -DSimpleITK_LUA_EXECUTABLE=$EBROOTLUA/bin/lua "
+
+# Install Python module as extension
+exts_defaultclass = 'PythonPackage'
+
+exts_list = [
+    (name, version, {
+        'modulename': '%(name)s',
+        'source_urls': ['https://github.com/%(name)s/%(name)s/releases/download/v%(version)s'],
+        'start_dir': '%(builddir)s/easybuild_obj/Wrapping/Python',
+        'checksums': ['1ef3642b0695c8eb0a0193fefe7677c57bce94a86d6b01f48f58b2291b4ca935'],
+    }),
+]
+
+sanity_check_paths = {
+    'files': ['lib/libSimpleITK_ITKBiasCorrection-%(version_major_minor)s.a'],
+    'dirs': ['include/%(name)s-%(version_major_minor)s', 'lib/python%(pyshortver)s/site-packages'],
+}
+
+moduleclass = 'tools'