diff --git a/.changeset/otel-get-route-callback.md b/.changeset/otel-get-route-callback.md
new file mode 100644
index 000000000..4f62a437f
--- /dev/null
+++ b/.changeset/otel-get-route-callback.md
@@ -0,0 +1,9 @@
+---
+'@hono/otel': minor
+---
+
+feat(otel): add `getRoute` config callback so downstream adapters can resolve `http.route`
+
+The middleware previously overwrote the `http.route` attribute on the active span with the matched Hono route pattern at finalize time, even when a downstream adapter (such as an RPC layer) had already set a more specific value on the span. The same pattern was also reported as the `http.route` attribute of the `http.server.request.duration` metric, so per-operation latency collapsed into the pattern bucket.
+
+`getRoute(c)` is now an optional config callback. When it returns a non-empty string it is used for both the span attribute and the metric attribute; when it returns `undefined`, an empty string, or throws, the middleware falls back to the existing `routePath(c)` behavior. This is fully backward compatible and resolves [issue #1914](https://github.com/honojs/middleware/issues/1914).
diff --git a/packages/otel/src/index.test.ts b/packages/otel/src/index.test.ts
index d2870e89e..b1d6b6a67 100644
--- a/packages/otel/src/index.test.ts
+++ b/packages/otel/src/index.test.ts
@@ -313,6 +313,71 @@ describe('OpenTelemetry middleware - Spans (combined)', () => {
     const spans = memoryExporter.getFinishedSpans()
     assert.strictEqual(spans.length, 0)
   })
+
+  // Regression tests for https://github.com/honojs/middleware/issues/1914 - a downstream
+  // adapter (such as an RPC layer) can now expose a resolved operation name via the
+  // `getRoute` config callback, and the span's `http.route` attribute reflects that
+  // value at finalize time instead of being overwritten with the Hono route pattern.
+  it('Should use getRoute return value for the span http.route attribute', async () => {
+    const app2 = new Hono()
+    app2.use(
+      httpInstrumentationMiddleware({
+        tracerProvider,
+        getRoute: (c: Context) => c.get('rpc.route' as never) as string | undefined,
+      })
+    )
+    app2.get('/rpc/*', (c) => {
+      c.set('rpc.route' as never, '/rpc/user/getProfile' as never)
+      return c.text('ok')
+    })
+    await app2.request('http://localhost/rpc/user/getProfile')
+    const [span] = memoryExporter.getFinishedSpans()
+    assert.strictEqual(span.attributes[ATTR_HTTP_ROUTE], '/rpc/user/getProfile')
+  })
+
+  it('Should fall back to routePath(c) when getRoute returns undefined', async () => {
+    const app2 = new Hono()
+    app2.use(
+      httpInstrumentationMiddleware({
+        tracerProvider,
+        getRoute: () => undefined,
+      })
+    )
+    app2.get('/rpc/*', (c) => c.text('ok'))
+    await app2.request('http://localhost/rpc/user/getProfile')
+    const [span] = memoryExporter.getFinishedSpans()
+    assert.strictEqual(span.attributes[ATTR_HTTP_ROUTE], '/rpc/*')
+  })
+
+  it('Should fall back to routePath(c) when getRoute returns an empty string', async () => {
+    const app2 = new Hono()
+    app2.use(
+      httpInstrumentationMiddleware({
+        tracerProvider,
+        getRoute: () => '',
+      })
+    )
+    app2.get('/rpc/*', (c) => c.text('ok'))
+    await app2.request('http://localhost/rpc/user/getProfile')
+    const [span] = memoryExporter.getFinishedSpans()
+    assert.strictEqual(span.attributes[ATTR_HTTP_ROUTE], '/rpc/*')
+  })
+
+  it('Should fall back to routePath(c) when getRoute throws', async () => {
+    const app2 = new Hono()
+    app2.use(
+      httpInstrumentationMiddleware({
+        tracerProvider,
+        getRoute: () => {
+          throw new Error('boom')
+        },
+      })
+    )
+    app2.get('/rpc/*', (c) => c.text('ok'))
+    await app2.request('http://localhost/rpc/user/getProfile')
+    const [span] = memoryExporter.getFinishedSpans()
+    assert.strictEqual(span.attributes[ATTR_HTTP_ROUTE], '/rpc/*')
+  })
 })
 
 describe('OpenTelemetry middleware - Metrics (combined)', () => {
@@ -558,4 +623,35 @@ describe('OpenTelemetry middleware - Metrics (combined)', () => {
 
     assert.strictEqual(adds.length, 0)
   })
+
+  // Regression test for https://github.com/honojs/middleware/issues/1914 - the resolved
+  // route from `getRoute` must also be applied to the `http.server.request.duration`
+  // histogram, so per-operation latency is not collapsed into the Hono pattern bucket.
+  it('Should use getRoute return value for the request duration metric http.route attribute', async () => {
+    const app = new Hono()
+    app.use(
+      httpInstrumentationMiddleware({
+        meterProvider: meterProvider as unknown as MeterProvider,
+        getRoute: (c: Context) => c.get('rpc.route' as never) as string | undefined,
+      })
+    )
+    app.get('/rpc/*', (c) => {
+      c.set('rpc.route' as never, '/rpc/user/getProfile' as never)
+      return c.text('ok')
+    })
+    await app.request('http://localhost/rpc/user/getProfile')
+    await metricReader.forceFlush()
+
+    const resourceMetrics = memoryMetricExporter.getMetrics()
+    assert.ok(resourceMetrics.length > 0)
+    const metrics = resourceMetrics[0].scopeMetrics[0].metrics
+    const durationMetric = metrics.find((m) => m.descriptor.name === 'http.server.request.duration')
+    assert.ok(durationMetric)
+    const dps = durationMetric.dataPoints as DataPoint<Histogram>[]
+    const dp = dps.find((d) => d.attributes['http.route'] === '/rpc/user/getProfile')
+    assert.ok(dp, 'expected a data point keyed by the resolved RPC route')
+    assert.strictEqual(dp.attributes['http.route'], '/rpc/user/getProfile')
+    assert.strictEqual(dp.attributes['http.request.method'], 'GET')
+    assert.strictEqual(dp.attributes['http.response.status_code'], 200)
+  })
 })
diff --git a/packages/otel/src/index.ts b/packages/otel/src/index.ts
index b9b43d45e..874d50f8e 100644
--- a/packages/otel/src/index.ts
+++ b/packages/otel/src/index.ts
@@ -116,8 +116,24 @@ export const httpInstrumentationMiddleware = (
         }
       } finally {
         activeReqs?.decrement(stableAttrs)
-        // Update route and name since they may have changed after routing finished
-        span?.setAttribute(ATTR_HTTP_ROUTE, routePath(c))
+        // Update route and name since they may have changed after routing finished.
+        // Prefer a value resolved by the user via `getRoute` (e.g. an RPC operation
+        // name that a downstream adapter has set on the context) over the matched
+        // Hono pattern, so adapters can surface the real operation in both the
+        // span attribute and the request duration metric.
+        let finalRoute = routePath(c)
+        if (config.getRoute) {
+          try {
+            const resolved = config.getRoute(c)
+            if (typeof resolved === 'string' && resolved.length > 0) {
+              finalRoute = resolved
+            }
+          } catch {
+            // Ignore errors from the user-supplied route resolver and fall back to
+            // the default pattern so the request still produces a clean span.
+          }
+        }
+        span?.setAttribute(ATTR_HTTP_ROUTE, finalRoute)
 
         span?.updateName(spanName(c))
         // Convert duration to seconds as the time unit from performance.now() is in milliseconds
@@ -125,7 +141,7 @@ export const httpInstrumentationMiddleware = (
 
         requestDuration.record(duration, {
           ...stableAttrs,
-          [ATTR_HTTP_ROUTE]: routePath(c),
+          [ATTR_HTTP_ROUTE]: finalRoute,
           [ATTR_HTTP_RESPONSE_STATUS_CODE]: c.res.status,
         })
       }
diff --git a/packages/otel/src/types.ts b/packages/otel/src/types.ts
index ae95937ca..f8667bfa8 100644
--- a/packages/otel/src/types.ts
+++ b/packages/otel/src/types.ts
@@ -11,6 +11,20 @@ export type HttpInstrumentationConfig = {
   getTime?(): TimeInput
   disableTracing?: boolean
   spanNameFactory?: (c: HonoContext) => string
+  /**
+   * Resolves the value of the `http.route` attribute used at finalize time
+   * for both the active span and the `http.server.request.duration` metric.
+   *
+   * Returning a non-empty string overrides the default, which is the Hono
+   * route pattern (for example `/rpc/*`). This is useful when a downstream
+   * adapter resolves a more specific route name during request handling
+   * (such as an RPC operation name) and you want both the span and the
+   * metric to carry that resolved value instead of the pattern.
+   *
+   * Returning `undefined` or throwing falls back to the default pattern, so
+   * the existing behavior is preserved when this hook is not provided.
+   */
+  getRoute?: (c: HonoContext) => string | undefined
   serviceName?: string
   serviceVersion?: string
 }