diff --git a/src/jsc/bindings/bindings.cpp b/src/jsc/bindings/bindings.cpp
index 31ba33ed07ef..b349481587ae 100644
--- a/src/jsc/bindings/bindings.cpp
+++ b/src/jsc/bindings/bindings.cpp
@@ -1793,8 +1793,9 @@ static std::optional<bool> specialObjectsDequalSlow(const DeepEqualsMode& mode,
                 return false;
             }
             if (mode.checkPrototypes) {
-                // node also compares `lastIndex` and own enumerable properties.
-                bool sameLastIndex = JSC::sameValue(globalObject, left->getLastIndex(), right->getLastIndex());
+                // node compares `lastIndex` with ===, not Object.is, then own enumerable properties:
+                // https://github.com/nodejs/node/blob/v26.12.1/lib/internal/util/comparisons.js#L148-L152
+                bool sameLastIndex = JSC::JSValue::strictEqual(globalObject, left->getLastIndex(), right->getLastIndex());
                 RETURN_IF_EXCEPTION(scope, {});
                 if (!sameLastIndex) {
                     return false;
diff --git a/src/jsc/modules/NodeUtilTypesModule.cpp b/src/jsc/modules/NodeUtilTypesModule.cpp
index 925fd83a6b7f..2e4f8cdb7e21 100644
--- a/src/jsc/modules/NodeUtilTypesModule.cpp
+++ b/src/jsc/modules/NodeUtilTypesModule.cpp
@@ -808,8 +808,9 @@ static bool compareBranch(JSC::JSGlobalObject* globalObject, JSC::MarkedArgument
         if (actualRegExp->regExp()->pattern() != expectedRegExp->regExp()->pattern()
             || actualRegExp->regExp()->flags() != expectedRegExp->regExp()->flags())
             return false;
-        // node also compares lastIndex strictly (comparisons.js isRegExp arm).
-        bool lastIndexEqual = JSC::sameValue(globalObject, actualRegExp->getLastIndex(), expectedRegExp->getLastIndex());
+        // node compares lastIndex with ===, not Object.is:
+        // https://github.com/nodejs/node/blob/v26.12.1/lib/internal/util/comparisons.js#L148-L152
+        bool lastIndexEqual = JSC::JSValue::strictEqual(globalObject, actualRegExp->getLastIndex(), expectedRegExp->getLastIndex());
         RETURN_IF_EXCEPTION(scope, false);
         if (!lastIndexEqual)
             return false;
diff --git a/test/js/node/assert/assert.test.cjs b/test/js/node/assert/assert.test.cjs
index a8a2043b730b..03b0449bd165 100644
--- a/test/js/node/assert/assert.test.cjs
+++ b/test/js/node/assert/assert.test.cjs
@@ -85,6 +85,45 @@ describe("assert.partialDeepStrictEqual", () => {
     assert.partialDeepStrictEqual({ arr: [shared, shared] }, { arr: [{ x: 1 }] });
   });
 
+  // Node's areSimilarRegExps() compares lastIndex with ===: -0 equals 0, NaN differs from NaN, "0" differs from 0.
+  // https://github.com/nodejs/node/blob/v26.12.1/lib/internal/util/comparisons.js#L148-L152
+  test.each([
+    ["at the top level", re => re],
+    ["in an array", re => [re]],
+    ["in an object property", re => ({ re })],
+    ["in a Map value", re => new Map([["k", re]])],
+    ["in a Map key", re => new Map([[re, 1]])],
+    ["in a Set", re => new Set([re])],
+    ["in an Error cause", re => new Error("e", { cause: re })],
+  ])("RegExp lastIndex is compared with === %s", (_name, wrap) => {
+    const withLastIndex = lastIndex => Object.assign(/a/g, { lastIndex });
+    const partial = (actual, expected) => {
+      try {
+        assert.partialDeepStrictEqual(wrap(actual), wrap(expected));
+        return "equal";
+      } catch (e) {
+        return e.code;
+      }
+    };
+    const sameObject = withLastIndex(NaN);
+    expect({
+      negativeZeroAndZero: partial(withLastIndex(-0), withLastIndex(0)),
+      zeroAndNegativeZero: partial(withLastIndex(0), withLastIndex(-0)),
+      nanAndNaN: partial(withLastIndex(NaN), withLastIndex(NaN)),
+      stringZeroAndZero: partial(withLastIndex("0"), withLastIndex(0)),
+      threeAndZero: partial(withLastIndex(3), withLastIndex(0)),
+      // The identity shortcut answers before lastIndex is read.
+      sameObjectWithNaN: partial(sameObject, sameObject),
+    }).toEqual({
+      negativeZeroAndZero: "equal",
+      zeroAndNegativeZero: "equal",
+      nanAndNaN: "ERR_ASSERTION",
+      stringZeroAndZero: "ERR_ASSERTION",
+      threeAndZero: "ERR_ASSERTION",
+      sameObjectWithNaN: "equal",
+    });
+  });
+
   test("a descendant actual identical to an ancestor expected is not mistaken for a cycle", () => {
     const e = { k: {} };
     assert.partialDeepStrictEqual({ k: e }, e);
diff --git a/test/js/node/assert/deep-equal.test.ts b/test/js/node/assert/deep-equal.test.ts
index abb31a1a0e3d..dc492f10699e 100644
--- a/test/js/node/assert/deep-equal.test.ts
+++ b/test/js/node/assert/deep-equal.test.ts
@@ -658,6 +658,62 @@ const cases: Case[] = [
   // RegExp.
   { name: "two equal regexps", a: () => /a/g, b: () => /a/g, strict: true, loose: true },
   { name: "regexps with different flags", a: () => /a/g, b: () => /a/i, strict: false, loose: false },
+  // lastIndex is compared with ===, not Object.is, in every mode.
+  {
+    name: "regexps with lastIndex -0 and 0",
+    a: () => Object.assign(/a/g, { lastIndex: -0 }),
+    b: () => /a/g,
+    strict: true,
+    loose: true,
+  },
+  {
+    name: "regexps with lastIndex NaN",
+    a: () => Object.assign(/a/g, { lastIndex: NaN }),
+    b: () => Object.assign(/a/g, { lastIndex: NaN }),
+    strict: false,
+    loose: false,
+    looseBug: "reports equal",
+  },
+  // A lastIndex of 0 and of -0 make two deep-equal members. The Set and Map walks take the
+  // first deep-equal member and do not pair members one to one.
+  // https://github.com/oven-sh/bun/issues/28760
+  {
+    name: "sets of three regexps with lastIndex 0, -0, 1 and 0, 1, 1",
+    a: () =>
+      new Set([
+        Object.assign(/a/g, { lastIndex: 0 }),
+        Object.assign(/a/g, { lastIndex: -0 }),
+        Object.assign(/a/g, { lastIndex: 1 }),
+      ]),
+    b: () =>
+      new Set([
+        Object.assign(/a/g, { lastIndex: 0 }),
+        Object.assign(/a/g, { lastIndex: 1 }),
+        Object.assign(/a/g, { lastIndex: 1 }),
+      ]),
+    strict: false,
+    loose: false,
+    strictBug: "reports equal",
+    looseBug: "reports equal",
+  },
+  // https://github.com/oven-sh/bun/issues/34830
+  {
+    name: "maps with two regexp keys whose lastIndex is 0 and -0",
+    a: () =>
+      new Map([
+        [Object.assign(/a/g, { lastIndex: 0 }), 1],
+        [Object.assign(/a/g, { lastIndex: -0 }), 2],
+      ]),
+    b: () =>
+      new Map([
+        [Object.assign(/a/g, { lastIndex: 0 }), 1],
+        [Object.assign(/a/g, { lastIndex: -0 }), 2],
+      ]),
+    strict: true,
+    loose: true,
+    strictBug: "reports not equal",
+    looseBug: "reports not equal",
+  },
   {
     name: "regexps with different lastIndex",
     a: () => Object.assign(/a/g, { lastIndex: 3 }),
@@ -1162,6 +1218,49 @@ describe("util.isDeepStrictEqual", () => {
     expect(calls).toBe(2);
   });
 
+  // Node's areSimilarRegExps() compares lastIndex with ===: -0 equals 0, NaN differs from NaN, "0" differs from 0.
+  // https://github.com/nodejs/node/blob/v26.12.1/lib/internal/util/comparisons.js#L148-L152
+  describe("RegExp lastIndex", () => {
+    const withLastIndex = (lastIndex: unknown) => Object.assign(/a/g, { lastIndex });
+    const positions: Array<[string, (re: RegExp) => unknown]> = [
+      ["at the top level", re => re],
+      ["in an array", re => [re]],
+      ["in an object property", re => ({ re })],
+      ["in a Map value", re => new Map([["k", re]])],
+      ["in a Map key", re => new Map([[re, 1]])],
+      ["in a Set", re => new Set([re])],
+      ["in an Error cause", re => new Error("e", { cause: re })],
+    ];
+
+    for (const [name, wrap] of positions) {
+      test(`is compared with === ${name}`, () => {
+        const sameObject = withLastIndex(NaN);
+        for (const skipPrototype of [false, true]) {
+          const equal = (a: RegExp, b: RegExp) => util.isDeepStrictEqual(wrap(a), wrap(b), skipPrototype as any);
+          assert.deepStrictEqual(
+            {
+              skipPrototype,
+              negativeZeroAndZero: equal(withLastIndex(-0), withLastIndex(0)),
+              zeroAndNegativeZero: equal(withLastIndex(0), withLastIndex(-0)),
+              nanAndNaN: equal(withLastIndex(NaN), withLastIndex(NaN)),
+              stringZeroAndZero: equal(withLastIndex("0"), withLastIndex(0)),
+              // The identity shortcut answers before lastIndex is read.
+              sameObjectWithNaN: equal(sameObject, sameObject),
+            },
+            {
+              skipPrototype,
+              negativeZeroAndZero: true,
+              zeroAndNegativeZero: true,
+              nanAndNaN: false,
+              stringZeroAndZero: false,
+              sameObjectWithNaN: true,
+            },
+          );
+        }
+      });
+    }
+  });
+
   // The third argument was added in Node v26.
   describe("skipPrototype", () => {
     class Foo {