Skip to content

Rosetta Commons Logo

Welcome to the Rosetta Commons GitHub Organization!

Rosetta Commons drives innovation in biomolecular modeling and design through cutting-edge computational methods and shared software. Our global community of scientists collaborates to advance open, reproducible science and accelerate discovery.

This GitHub organization hosts the tools our community has built – from the original physics-based Rosetta software to the latest ML-driven methods for protein design.

What you'll find here

  • Physics-based tools: The original Rosetta suite for structure prediction, docking, and design
  • ML-based tools: Community-built deep learning methods developed over the past several years
  • Support resources: Documentation and community guidance for every experience level

Getting Started

Not sure where to begin? The Software Download page has an overview of all available repositories with their support levels, so you can find the right tool for your pipeline. For broader context on our organization and mission, visit the Rosetta Commons website.

Pinned Loading

  1. rosetta rosetta Public

    The Rosetta Bio-macromolecule modeling package. Available through license with the University of Washington.

    C++ 439 160

  2. PyRosetta.notebooks PyRosetta.notebooks Public

    Jupyter Notebooks for learning the PyRosetta platform for biomolecular structure prediction and design

    Jupyter Notebook 693 169

  3. RFdiffusion RFdiffusion Public

    Code for running RFdiffusion

    Python 2.9k 620

  4. binder binder Public

    Binder, tool for automatic generation of Python bindings

    C++ 366 70

  5. foundry foundry Public

    Central repository for biomolecular foundation models with shared trainers and pipeline components

    Python 838 150

  6. atomworks atomworks Public

    A generalized computational framework for biomolecular modeling.

    Python 423 45

Repositories

Showing 10 of 52 repositories

Top languages

Loading…

Most used topics

Loading…